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Updated: Aug 24, 2025
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
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Evidence-based updates to the 2021 Surviving Sepsis Campaign guidelines: Part 1: Background, pathophysiology, and
1Karen D. Lehman is a hospitalist NP and PRN ED NP at NMC Health in Newton, Kan., an ED NP with Docs Who Care based in Olathe, Kan., and a hospice NP with Harry Hynes Memorial Hospice in Wichita, Kan.
The Nurse Practitioner
|October 26, 2022
Summary
Sepsis management has evolved, yet significant mortality persists. This review covers sepsis history, pathophysiology, and new research in treatment and recovery.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Medical History
Background:
- Sepsis remains a major global health challenge with high morbidity and mortality rates.
- Despite advances in identification and treatment, outcomes for sepsis patients have not improved proportionally.
Purpose of the Study:
- To review the historical evolution of modern sepsis understanding and management.
- To present current research on sepsis pathophysiology, therapeutic interventions, and postsepsis care.
Main Methods:
- Literature review of historical sepsis definitions and diagnostic criteria.
- Synthesis of recent research findings on sepsis mechanisms and treatment strategies.
Main Results:
- Significant changes in sepsis identification and treatment over recent decades.
- Ongoing challenges in reducing sepsis-associated morbidity and mortality.
Conclusions:
- Understanding the history of sepsis is crucial for appreciating current research.
- New research in pathophysiology, treatment, and postsepsis care offers potential for improved patient outcomes.
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