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COVID-19 Vaccine Booster Dose Acceptance: Systematic Review and Meta-Analysis
Shaimaa Abdelaziz Abdelmoneim1, Malik Sallam2,3, Dina Mohamed Hafez4
1Clinical Research Administration, Alexandria Directorate of Health Affairs, Egyptian Ministry of Health and Population, Alexandria 21554, Egypt.
Tropical Medicine and Infectious Disease
|October 26, 2022
Summary
Global COVID-19 vaccine booster acceptance is high at 81%, but actual uptake is only 31%. Public health campaigns are crucial to increase booster dose uptake and achieve herd immunity for better pandemic control.
Area of Science:
- Public Health
- Epidemiology
- Vaccinology
Background:
- The World Health Organization (WHO) recommends COVID-19 booster doses for individuals aged 18 and above and high-risk groups.
- Understanding the uptake and intention for booster doses is critical for controlling the COVID-19 pandemic.
Purpose of the Study:
- To estimate the pooled proportion of COVID-19 vaccine booster dose uptake and acceptance.
- To assess booster dose intention among general populations and healthcare workers (HCWs).
Main Methods:
- A systematic literature search was conducted across multiple databases following PRISMA guidelines.
- Meta-analysis was performed on 48 high-quality studies involving 198,831 participants.
- Newcastle-Ottawa Scale was used for quality assessment of the included studies.
Main Results:
- The pooled acceptance rate for COVID-19 vaccine booster doses was 81% (95% CI: 75-85%).
- Actual booster dose uptake was significantly lower at 31% (95% CI: 19-46%), while intention was 79% (95% CI: 72-85%).
- Acceptance varied by WHO region, with the Western Pacific showing the highest (89%) and Southeast Asia the lowest (52%). Previous COVID-19 infection was linked to lower intention but higher actual uptake.
- Healthcare workers showed a 66% acceptance rate. Chronic disease and trust in vaccine effectiveness predicted higher acceptance.
Conclusions:
- While global acceptance of COVID-19 booster vaccines is high, actual uptake and regional variations necessitate targeted interventions.
- Previous COVID-19 infection influences booster dose intention and uptake differently.
- Intensified vaccination campaigns are essential to raise awareness and improve booster dose acceptance for achieving herd immunity and pandemic control.
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