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Mott Cell Differentiation in Canine Multicentric B Cell Lymphoma with Cross-Lineage Rearrangement and Lineage
Woo-Sub Kim1, Kun-Ho Song1, Hyeona Bae2
1Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.
Veterinary Sciences
|October 26, 2022
Summary
This study reports a rare case of canine multicentric B-cell lymphoma with Mott cell differentiation, cross-lineage rearrangement, and lineage infidelity. The aggressive cancer showed a poor response to chemotherapy, leading to a fatal outcome.
Area of Science:
- Veterinary Oncology
- Immunology
Background:
- Lymphoma, characterized by neoplastic lymphoid cell proliferation, is a severe condition in dogs.
- Multicentric B-cell lymphoma (MCL) with Mott cell differentiation is rarely documented in veterinary literature.
Observation:
- A 4-year-old dog presented with lymphadenopathy and abdominal enlargement.
- Blood analysis revealed lymphocytosis, lymphoblastosis, and Mott cells.
- Fine needle aspiration cytology confirmed a predominant population of lymphoblasts and Mott cells.
Findings:
- The dog was diagnosed with leukemic state multicentric B-cell lymphoma with Mott cell differentiation.
- The patient exhibited cross-lineage rearrangement (CLRA) and lineage infidelity (LI) via PCR and flow cytometry.
- The lymphoma showed progressive disease despite CHOP-based chemotherapy, resulting in death within three months.
Implications:
- This case highlights an unusual clinical course for canine B-cell lymphoma with Mott cell differentiation.
- The co-occurrence of CLRA and LI in canine MCL is unprecedented.
- This report contributes novel insights into the complex biology and behavior of canine lymphoma.
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