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Effect of ascorbic acid on brain amphetamine concentrations in the rat.
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|January 1, 1987
Summary
Ascorbic acid does not affect amphetamine levels in the rat brain or alter amphetamine-induced behaviors. These findings suggest ascorbic acid does not impact amphetamine pharmacokinetics.
Area of Science:
- Pharmacology
- Neuroscience
- Biochemistry
Background:
- Ascorbic acid, also known as vitamin C, has been suggested to possess antiamphetamine properties.
- Rodent studies have indicated potential interactions between ascorbic acid and amphetamine.
Purpose of the Study:
- To investigate the effect of ascorbic acid on amphetamine pharmacokinetics in the rat brain.
- To determine if ascorbic acid influences amphetamine-induced stereotyped behavior.
Main Methods:
- Rats were administered ascorbic acid (1 g/kg) and amphetamine (10 mg/kg).
- Brain tissue was analyzed for 3H-amphetamine levels to determine half-life.
- Amphetamine-induced stereotyped behavior was quantified.
Main Results:
- Ascorbic acid administration did not alter the half-life of amphetamine in rat brain.
- Ascorbic acid did not significantly affect amphetamine-induced stereotyped behavior.
Conclusions:
- Ascorbic acid does not appear to antagonize amphetamine's behavioral effects by altering its pharmacokinetics.
- The proposed antiamphetamine effects of ascorbic acid may not be mediated through changes in amphetamine brain levels or metabolism.