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An explanatory hypothesis for early- and late-effect parameter values in the LQ model

T E Schultheiss, G K Zagars, L J Peters

    Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
    |July 1, 1987
    PubMed
    Summary

    Cell population heterogeneity introduces higher-order dose terms in the linear-quadratic (LQ) model, affecting radiobiology calculations. This heterogeneity explains observed dose-response curves and biases LQ parameter estimations.

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