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Set and setting in microdosing: an oft-overlooked principle.

Ido Hartogsohn1, Rotem Petranker2

  • 1The Program for Science, Technology and Society Studies, Bar Ilan University, Ramat Gan, Israel.

Psychopharmacology
|October 26, 2022
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Summary
This summary is machine-generated.

Set and setting significantly influence psychedelic microdosing outcomes. Reporting these contextual factors, including expectancy and environment, is crucial for consistent and reliable microdosing research findings.

Keywords:
LSDMicrodosingPsilocybinPsychedelicsSet and setting

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Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Clinical Psychology

Background:

  • Psychedelic use for medical and recreational purposes is increasing.
  • Contextual factors like expectancy, intention, and environment (set and setting) are known to modulate psychedelic effects.
  • Clinical trials for psychedelic microdosing often omit set and setting details, implying their diminished importance.

Purpose of the Study:

  • To challenge the assumption that set and setting are unimportant in microdosing.
  • To argue for the critical relevance of set and setting in psychedelic microdosing practices.
  • To explain the importance of set and setting in microdosing by integrating set and setting theory and placebo theory.

Main Methods:

  • Theoretical analysis integrating set and setting theory.
  • Theoretical analysis integrating placebo theory.
  • Literature review on psychedelic microdosing research.

Main Results:

  • Set and setting play a crucial role in determining microdosing outcomes.
  • The influence of set and setting helps explain inconsistencies in current microdosing research.
  • Understanding set and setting is key to interpreting variable results in microdosing studies.

Conclusions:

  • Set and setting are vital considerations, particularly in psychedelic microdosing.
  • Standardized reporting of set and setting can enhance the reliability and consistency of microdosing research.
  • Future microdosing studies should meticulously document set and setting to improve scientific rigor.