Therapeutic Antiaging Strategies

Area of Science:

• Gerontology and cellular biology.
• Focuses on the biological mechanisms of aging.

Background:

• Aging is a complex process involving progressive physiological decline.
• Characterized by nine hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.
• These hallmarks contribute to age-related diseases like cardiovascular diseases, neurodegenerative diseases, and cancer.

Purpose of the Study:

• To review the nine hallmarks of aging.
• To examine their contribution to age-related pathologies.
• To highlight proposed therapeutic strategies for healthy aging.

Main Methods:

• Comprehensive literature review of aging hallmarks.
• Analysis of in vitro and in vivo antiaging research.
• Synthesis of data on therapeutic interventions.

Main Results:

• Detailed examination of the nine hallmarks of aging and their roles.
• Identification of risk factors for major age-related diseases.
• Compilation of various antiaging strategies.

Conclusions:

• Understanding aging hallmarks is crucial for developing interventions.
• Therapeutic strategies aim to slow aging, reduce disease risk, and improve longevity.
• Focus on preventive measures, systemic agents, and invasive procedures for healthy aging.