Atherosclerosis by Virus Infection-A Short Review

Seang-Hwan Jung1, Kyung-Tae Lee1,2

  • 1Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02247, Korea.

Biomedicines
|October 27, 2022
PubMed

Insights

Viruses like influenza and herpes can cause atherosclerosis, a cardiovascular disease indicated by plaque buildup in arteries. This review details viral links, mechanisms, and treatments for virus-induced atherosclerosis.

Area of Science:

  • Cardiovascular Science
  • Infectious Disease
  • Pathology

Background:

  • Atherosclerosis, characterized by arterial plaque buildup, is a major cardiovascular disease risk factor.
  • While traditional risk factors include smoking and hypertension, infections are increasingly recognized as contributors.
  • Viruses such as influenza, herpes, hepatitis, papillomaviruses, and SARS-CoV-2 are implicated in atherosclerosis development.

Purpose of the Study:

  • To review viruses associated with atherosclerosis development.
  • To elucidate the viral characteristics and pathogenic mechanisms involved.
  • To summarize current therapeutic strategies, including vaccines and antiviral treatments.

Main Methods:

  • Literature review of scientific articles and research papers.
  • Analysis of viral characteristics and their role in atherogenesis.
  • Synthesis of information on disease mechanisms and treatment options.

Main Results:

  • Several prevalent viruses are linked to the development of atherosclerosis.
  • Viral infections can trigger inflammatory and immune responses contributing to plaque formation.
  • COVID-19 patients frequently exhibit cardiovascular complications, suggesting viral impact.

Conclusions:

  • Viral infections represent a significant, often overlooked, cause of atherosclerosis.
  • Understanding viral mechanisms is crucial for developing targeted prevention and treatment strategies.
  • Further research into antiviral therapies and vaccines is warranted for managing virus-associated cardiovascular disease.

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