Atherosclerosis by Virus Infection-A Short Review
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Updated: Aug 24, 2025

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
Seang-Hwan Jung1, Kyung-Tae Lee1,2
1Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02247, Korea.
Insights
Viruses like influenza and herpes can cause atherosclerosis, a cardiovascular disease indicated by plaque buildup in arteries. This review details viral links, mechanisms, and treatments for virus-induced atherosclerosis.
Area of Science:
- Cardiovascular Science
- Infectious Disease
- Pathology
Background:
- Atherosclerosis, characterized by arterial plaque buildup, is a major cardiovascular disease risk factor.
- While traditional risk factors include smoking and hypertension, infections are increasingly recognized as contributors.
- Viruses such as influenza, herpes, hepatitis, papillomaviruses, and SARS-CoV-2 are implicated in atherosclerosis development.
Purpose of the Study:
- To review viruses associated with atherosclerosis development.
- To elucidate the viral characteristics and pathogenic mechanisms involved.
- To summarize current therapeutic strategies, including vaccines and antiviral treatments.
Main Methods:
- Literature review of scientific articles and research papers.
- Analysis of viral characteristics and their role in atherogenesis.
- Synthesis of information on disease mechanisms and treatment options.
Main Results:
- Several prevalent viruses are linked to the development of atherosclerosis.
- Viral infections can trigger inflammatory and immune responses contributing to plaque formation.
- COVID-19 patients frequently exhibit cardiovascular complications, suggesting viral impact.
Conclusions:
- Viral infections represent a significant, often overlooked, cause of atherosclerosis.
- Understanding viral mechanisms is crucial for developing targeted prevention and treatment strategies.
- Further research into antiviral therapies and vaccines is warranted for managing virus-associated cardiovascular disease.
Abstract:
Atherosclerosis manifests by the thickening of artery walls and their narrowed channels through the accumulation of plaque. It is one of the most important indicators of cardiovascular disease. It can be caused by various factors, such as smoking, a high cholesterol diet, hypertension, hyperglycemia, and genetic factors. However, atherosclerosis can also develop due to infection. It has been reported that some bacteria and viruses can cause the development of atherosclerosis. Examples of these viruses are influenza viruses, herpes viruses, hepatitis viruses, or papillomaviruses, which are all prevalent and eminent globally for infecting the population worldwide. Moreover, many patients with coronavirus disease 2019 (COVID-19) showed symptoms of cardiovascular disease. In this review paper, the viruses linked to the development of atherosclerosis are introduced, and their viral characteristics, the mechanisms of the development of atherosclerosis, and the current vaccines and antiviral treatment methods are summarized.
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