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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Nrf2 Modulation in Breast Cancer.

Somayyeh Ghareghomi1, Mehran Habibi-Rezaei2,3, Marzia Arese4

  • 1Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417466191, Iran.

Biomedicines
|October 27, 2022
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Summary

Reactive oxygen species (ROS) impact cell survival and death. This review explores Nrf2 pathway modulators for sensitizing breast cancer cells to therapy.

Keywords:
Keap1-Nrf2Nrf2 inhibitorsantioxidant pathwaybreast canceroxidative stress

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Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Reactive oxygen species (ROS) are crucial signaling molecules influencing cellular processes like proliferation, apoptosis, and differentiation.
  • Oxidative stress and inflammation are implicated in various pathologies, including cancer and neurodegenerative diseases.
  • The Keap1-Nrf2 pathway is a key regulator of antioxidant responses, balancing cell survival and death.

Purpose of the Study:

  • To review the dual role of the Nrf2 pathway in cancer progression and suppression.
  • To investigate Nrf2 modulators for their potential in cancer therapy.
  • To focus on sensitizing breast cancer cells to chemotherapy and radiotherapy agents.

Main Methods:

  • Literature review of studies on ROS, oxidative stress, and the Keap1-Nrf2 pathway.
  • Analysis of Nrf2 pathway activation and its impact on cancer cell survival.
  • Examination of Nrf2 modulators and their effects on chemo/radiotherapy sensitivity.

Main Results:

  • Nrf2 pathway activation can be protective in early cancer stages by reducing ROS.
  • Hyperactivation of Keap1-Nrf2 can promote cancer cell survival against oxidative stress and treatments.
  • Targeting Nrf2 presents a potential strategy for enhancing cancer treatment efficacy.

Conclusions:

  • The Nrf2 pathway has a complex, context-dependent role in cancer.
  • Modulating Nrf2 activity offers a promising therapeutic avenue for breast cancer treatment.
  • Further research into specific Nrf2 modulators is warranted to optimize cancer therapy.