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Related Experiment Videos

Leukocyte alkaline phosphatase.

D B Okun, K R Tanaka

    American Journal of Hematology
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Leukocyte alkaline phosphatase (LAP) levels change in various conditions, aiding diagnosis but not solely identifying diseases. Its precise function remains unknown, requiring integration with other clinical data.

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    Area of Science:

    • Biochemistry
    • Enzymology
    • Clinical Diagnostics

    Background:

    • Leukocyte alkaline phosphatase (LAP) is an enzyme with a poorly understood function.
    • LAP activity is linked to pituitary-adrenal function.
    • Changes in LAP activity are observed in various physiological and pathological states.

    Purpose of the Study:

    • To review alterations in LAP activity during different conditions.
    • To explore the diagnostic utility of LAP levels in disease states.
    • To highlight the role of LAP in differentiating specific hematological disorders.

    Main Methods:

    • Literature review of studies reporting LAP activity.
    • Analysis of conditions with consistently altered LAP levels.
    • Comparison of LAP values in differentiating CML from other leukocytosis conditions.

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    Main Results:

    • LAP activity is altered in several physiological and disease states.
    • Consistent LAP alterations can aid in diagnosing certain disorders.
    • LAP is particularly useful in distinguishing chronic myeloid leukemia (CML) from leukemoid reactions.

    Conclusions:

    • LAP is an enzyme of interest, with its control related to pituitary-adrenal function.
    • While LAP alterations are informative, LAP values alone are not diagnostic.
    • LAP should be used as a laboratory test in conjunction with comprehensive clinical data.