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Lactic acidosis and diffuse histiocytic lymphoma (DHL).
American Journal of Hematology
|January 1, 1978
Summary
Lactic acidosis in advanced diffuse histiocytic lymphoma may stem from liver infiltration. Early chemotherapy can help manage this condition, improving patient outcomes and correcting lactic acidosis.
Area of Science:
- Oncology
- Hematology
- Medical Biochemistry
Background:
- Diffuse histiocytic lymphoma (DHL) is an aggressive non-Hodgkin lymphoma.
- Lactic acidosis is a serious metabolic complication that can occur in various cancers.
- Disturbed liver function tests are common in advanced malignancies.
Observation:
- Four patients with advanced DHL presented with lactic acidosis.
- All patients exhibited abnormal liver function tests.
- Two cases of lactic acidosis were refractory to treatment.
Findings:
- One patient achieved remission and lactic acidosis correction with early combination chemotherapy.
- Another patient's lactic acidosis abated with chemotherapy, but they succumbed to pulmonary embolism.
- Extensive hepatic infiltration is a probable contributor to lactic acidosis in DHL.
Implications:
- Early initiation of antineoplastic therapy may be crucial for managing lactic acidosis in DHL.
- Monitoring liver function is important in patients with advanced DHL.
- Understanding the link between hepatic infiltration and lactic acidosis can guide treatment strategies.