Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

AI/ML-Assisted SERS Biosensing for Biomolecular Detection: From Direct Spectral Response to Integrated Diagnostic Systems.

Biosensors·2026
Same author

Artificial Intelligence-Aided Microfluidic Cell Culture Systems.

Biosensors·2026
Same author

Microscale Flow Control and Droplet Generation Using Arduino-Based Pneumatically-Controlled Microfluidic Device.

Biosensors·2024
Same author

Experimental Study on Ion Transport in Microfluidic Electrodialysis Using Partially Masked Ion Exchange Membranes.

Micromachines·2022
Same author

Machine Learning-Based Heavy Metal Ion Detection Using Surface-Enhanced Raman Spectroscopy.

Sensors (Basel, Switzerland)·2022
Same author

SERSNet: Surface-Enhanced Raman Spectroscopy Based Biomolecule Detection Using Deep Neural Network.

Biosensors·2021
Same journal

A Coumarin-Based Probe for Sequential ON-OFF-ON Detection of Cu<sup>2+</sup> and Biothiols: Naked-Eye Detection, Smartphone RGB Readout and In Vivo Imaging.

Biosensors·2026
Same journal

Electropolymerized Molecularly Imprinted Polymers Supported on Carbon-Based Materials for (Bio)sensing: Direct and Indirect Detection Strategies.

Biosensors·2026
Same journal

Progress in (Photo)electrochemical Biosensors for the Detection of Amyloid-Beta Oligomer.

Biosensors·2026
Same journal

Design and Simulation of Lamotrigine Intermittent Release from a Subcutaneous Implant with an Enzymatic Biosensor Based on Clinical Data.

Biosensors·2026
Same journal

Prediction of Chronic Kidney Disease Based on Simulated Serum Analysis by Vibrational Spectroscopy.

Biosensors·2026
See all related articles

Related Experiment Video

Updated: Aug 23, 2025

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
07:51

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

7.5K

Polymeric Microfluidic Devices Fabricated Using Epoxy Resin for Chemically Demanding and Day-Long Experiments.

Jaeseok Lee1,2, Minseok Kim1,2

  • 1Department of Mechanical System Engineering, Kumoh National Institute of Technology, Gumi 39177, Korea.

Biosensors
|October 27, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a new method for creating rigid polymer microfluidic devices using epoxy resin, overcoming the limitations of flexible polydimethylsiloxane (PDMS) for demanding lab-on-chip applications.

Keywords:
epoxy resinmicrofluidicsparticle compartmentalizationpolymeric devicesoft lithography

More Related Videos

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications
05:33

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

8.9K
Microfluidic Devices for Characterizing Pore-scale Event Processes in Porous Media for Oil Recovery Applications
08:38

Microfluidic Devices for Characterizing Pore-scale Event Processes in Porous Media for Oil Recovery Applications

Published on: January 16, 2018

10.5K

Related Experiment Videos

Last Updated: Aug 23, 2025

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
07:51

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

7.5K
Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications
05:33

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

8.9K
Microfluidic Devices for Characterizing Pore-scale Event Processes in Porous Media for Oil Recovery Applications
08:38

Microfluidic Devices for Characterizing Pore-scale Event Processes in Porous Media for Oil Recovery Applications

Published on: January 16, 2018

10.5K

Area of Science:

  • Materials Science
  • Microfluidics
  • Polymer Chemistry

Background:

  • Polydimethylsiloxane (PDMS) is common for microfluidic devices due to rapid prototyping.
  • PDMS's elasticity causes deformation, limiting experimental robustness.
  • PDMS permeability and absorption issues restrict its use in demanding chemical applications.

Purpose of the Study:

  • Develop a rapid, reproducible method for fabricating rigid, polymer-based microfluidic devices.
  • Address the limitations of PDMS, including structural instability and chemical incompatibility.
  • Demonstrate the suitability of epoxy resin devices for chemically and physically demanding experiments.

Main Methods:

  • Optimized a high-resolution epoxy casting protocol using PDMS soft molds.
  • Compared structural robustness by tracking particle velocity changes in PDMS vs. polymer channels.
  • Evaluated chemical resistance by measuring hydrophobic chemical adsorption and water pervaporation.

Main Results:

  • Developed a repeatable fabrication protocol for rigid polymer microfluidic devices.
  • Demonstrated superior structural integrity and minimal deformation under flow compared to PDMS.
  • Showcased excellent chemical resistance, preventing molecule adsorption and water loss, suitable for long experiments.

Conclusions:

  • Rigid epoxy resin microfluidic devices offer a robust alternative to PDMS.
  • These devices are suitable for chemically and physically demanding lab-on-chip applications.
  • Enables advanced applications like HPLC, anaerobic cultures, and PCR.