Articular Cartilage Regeneration through Bioassembling Spherical Micro-Cartilage Building Blocks

Area of Science:

• Regenerative Medicine
• Biotechnology
• Tissue Engineering

Background:

• Articular cartilage lesions are common, affecting millions and lacking natural regeneration capacity.
• Current treatments for cartilage damage have significant limitations.
• Cartilage tissue engineering offers a promising alternative for repair and regeneration.

Purpose of the Study:

• To summarize and highlight the application of bioassembly technology in articular cartilage regeneration.
• To discuss the advantages and building blocks of bioassembly for cartilage repair.
• To analyze literature trends and discuss future directions for bioassembly in cartilage regeneration.

Main Methods:

• Review of 5069 articles published over the last 28 years.
• Analysis of research trends in seven categories related to bioassembly for cartilage.
• Discussion of building block types (spheroids, microspheres) and bioassembly techniques (bioprinting, non-bioprinting).

Main Results:

• Bioassembly utilizes microtissues as building blocks for constructing macro-tissues.
• Two primary building block types include scaffold-free spheroids and cell-laden microspheres.
• Literature analysis reveals trends and identifies key research areas in bioassembly for cartilage.

Conclusions:

• Bioassembly is an emerging and promising technology for articular cartilage regeneration.
• The technology offers advantages over existing methods for treating cartilage lesions.
• Further research and development are needed to address limitations and optimize future applications.