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Updated: Aug 23, 2025

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Neutral CB1 Receptor Antagonists as Pharmacotherapies for Substance Use Disorders: Rationale, Evidence, and Challenge

Omar Soler-Cedeno1, Zheng-Xiong Xi1

  • 1Addiction Biology Unit, Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA.

Cells
|October 27, 2022
PubMed

Keywords:
AM4113CB1 receptorPIMSRcannabinoidinverse agonistneutral antagonistrimonabantsubstance use disordersΔ9-tetrahydrocannabinol

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