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Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
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The SOCE Machinery: An Unbalanced Knowledge between Left and Right Ventricular Pathophysiology
Jessica Sabourin1, Antoine Beauvais2,3,4, Rui Luo1
1Signalisation et Physiopathologie Cardiovasculaire, Inserm, Université Paris-Saclay, UMR-S 1180, 91400 Orsay, France.
Cells
|October 27, 2022
Summary
Right ventricular failure is a key factor in heart disease mortality. This study explores store-operated calcium entry
Area of Science:
- Cardiovascular Physiology
- Molecular Cardiology
- Pulmonary Hypertension Research
Background:
- Right ventricular failure (RVF) is a critical determinant of mortality in pulmonary hypertension (PH).
- Right ventricle (RV) remodeling mechanisms remain understudied, hindering targeted therapeutic development.
- RV physiology differs significantly from left ventricle (LV) physiology, precluding direct translation of LV dysfunction knowledge.
Purpose of the Study:
- To review the current understanding of store-operated calcium entry (SOCE) in both LV and RV dysfunction.
- To emphasize the need for further research into RV remodeling and SOCE's role.
Main Methods:
- Literature review focusing on SOCE mechanisms in cardiac dysfunction.
- Analysis of existing studies on SOCE in LV and RV cardiomyocytes.
- Synthesis of current knowledge regarding SOCE's contribution to RV remodeling and failure.
Main Results:
- Store-operated calcium entry (SOCE) plays a role in cardiomyocyte calcium homeostasis and dysfunction in the LV.
- SOCE molecules are present in both LV and RV, suggesting a potential role in RV function.
- Limited research exists on SOCE's specific contribution to RV dysfunction compared to LV.
Conclusions:
- SOCE is implicated in cardiac calcium mishandling and dysfunction in the left ventricle.
- Further investigation into the role of SOCE in right ventricular remodeling and failure is crucial.
- Addressing the knowledge gap in RV dysfunction is essential for future therapeutic strategies in PH.
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