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Updated: Aug 23, 2025

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research
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Odor Pleasantness Modulates Functional Connectivity in the Olfactory Hedonic Processing Network.

Veit Frederik Kepler1, Manuel S Seet2, Junji Hamano3

  • 1Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore 117583, Singapore.

Brain Sciences
|October 27, 2022
PubMed
Summary
This summary is machine-generated.

Brain connectivity patterns during olfactory perception change based on odor pleasantness. This study used electroencephalography (EEG) to reveal distinct functional interactions in olfactory and reward brain regions.

Keywords:
brain connectivityelectroencephalographyhedonic evaluationlateralizationolfaction

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Area of Science:

  • Neuroscience
  • Olfactory Perception
  • Sensory Processing

Background:

  • Olfactory hedonic evaluation is crucial for smell perception, involving sensory, affective, and reward brain networks.
  • Understanding brain communication during olfactory pleasantness evaluation and its oscillatory mechanisms remains challenging.

Purpose of the Study:

  • To investigate functional interactions among brain areas during olfactory hedonic evaluation using electroencephalography (EEG).
  • To identify changes in functional connectivity networks in response to odor stimuli with varying hedonic values.

Main Methods:

  • Utilized electroencephalography (EEG) to record brain activity.
  • Estimated functional connectivity networks using the weighted phase lag index (wPLI) based on phase synchronization.
  • Applied graph theory metrics to quantify changes in functional connectivity within relevant brain regions.

Main Results:

  • Odor stimuli with different hedonic values elicited distinct interaction patterns in the olfactory cortex, anterior cingulate cortex, and orbitofrontal cortex.
  • Observed significant hemispheric laterality effects in the prefrontal and anterior cingulate cortices.
  • Identified specific involvement of beta and gamma frequency bands in these laterality effects.

Conclusions:

  • Odor pleasantness significantly modulates functional brain network interactions within key olfactory and reward processing areas.
  • Hemispheric lateralization in specific frequency bands (beta and gamma) is associated with olfactory hedonic evaluation.