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Adenomyosis-Associated Ischemic Stroke: Pathophysiology, Detection and Management
Yuying Yan1, Xuening Zhang1, Di Zhong1
1Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.
Brain Sciences
|October 27, 2022
Summary
Adenomyosis, a uterine condition, is an underrecognized risk factor for ischemic stroke in women. Biomarkers like elevated CA-125 and D-dimer suggest hypercoagulability may link adenomyosis to stroke.
Area of Science:
- Neurology
- Gynecology
- Vascular Medicine
Background:
- Female-specific stroke risk factors are gaining attention.
- Adenomyosis, a common benign uterine disorder in parous women, is an underrecognized contributor to ischemic stroke.
- Understanding this link is crucial for women's health.
Purpose of the Study:
- To review the epidemiology, pathophysiology, clinical features, diagnosis, and treatment of adenomyosis-associated ischemic stroke.
- To analyze existing literature and present a case study.
- To identify knowledge gaps and suggest future research directions.
Main Methods:
- A narrative review of studies on ischemic stroke and adenomyosis published up to April 2022.
- Keyword searches in English and Chinese databases.
- Analysis of data from 32 reported cases.
Main Results:
- Biomarkers for adenomyosis-associated ischemic stroke include elevated carbohydrate antigen 125 (CA-125) and D-dimer, with decreased hemoglobin.
- Hypercoagulability is a potential key mechanism for cerebrovascular thromboembolism.
- The condition is considered rare but significant for specific patient groups.
Conclusions:
- Further research is needed to establish optimal prevention strategies for adenomyosis-associated ischemic stroke.
- Recognizing this association can improve diagnosis and prevention in middle-aged women with cryptogenic stroke.
- This understanding contributes to personalized stroke risk assessment in women.
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