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Related Concept Videos

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An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group
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Methods for Radiolabelling Nanoparticles: SPECT Use (Part 1).

Michela Varani1, Valeria Bentivoglio1, Chiara Lauri1

  • 1Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, 00189 Roma, Italy.

Biomolecules
|October 27, 2022
PubMed
Summary
This summary is machine-generated.

Nanoparticles (NPs) are increasingly used in nuclear medicine for diagnostics and therapy. This review compares radiolabelling methods for NPs in single-photon emission computed tomography (SPECT) applications.

Keywords:
SPECT/CTnanoparticlesnanotechnologynuclear medicineradiolabelling

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Area of Science:

  • Nuclear Medicine
  • Nanotechnology
  • Radiochemistry

Background:

  • Nanoparticles (NPs) offer unique chemical-physical properties for molecular delivery.
  • Their size, shape, and composition influence in vivo behavior and targeting.
  • NPs can be functionalized with radionuclides for diagnostic and therapeutic applications, forming theranostic tools.

Purpose of the Study:

  • To review and compare various radiolabelling methods for nanoparticles.
  • To focus on methods suitable for single-photon emission computed tomography (SPECT) applications.

Main Methods:

  • Analysis of existing literature on nanoparticle radiolabelling techniques.
  • Comparison of methods based on nanoparticle properties and isotope characteristics.
  • Evaluation of suitability for SPECT imaging.

Main Results:

  • Multiple radiolabelling strategies exist for nanoparticles.
  • Method selection depends on NP characteristics and the specific radionuclide.
  • Different methods offer varying efficiencies and stabilities for SPECT applications.

Conclusions:

  • Radiolabelling is crucial for developing nanoparticle-based theranostic agents.
  • Choosing the appropriate radiolabelling method is key for successful SPECT imaging.
  • Further research can optimize NP radiolabelling for enhanced nuclear medicine applications.