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Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure

Vesna Degoricija1,2, Iva Klobučar3, Ines Potočnjak4

  • 1School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.

Biomolecules
|October 27, 2022
PubMed

Insights

The cholesterol content of very-low-density lipoprotein (VLDL-C/VLDL-apoB) may predict 1-year mortality in acute heart failure (AHF) patients. This finding offers potential prognostic value for managing AHF.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Biochemistry

Background:

  • Metabolic derangement correlates with heart failure severity.
  • Very-low-density lipoprotein (VLDL) lipid content is investigated for prognostic implications.

Purpose of the Study:

  • To assess the prognostic value of VLDL lipid content for 1-year mortality in acute heart failure (AHF).
  • To determine if VLDL particle composition predicts outcomes in AHF patients.

Main Methods:

  • NMR spectroscopy was used to measure baseline serum VLDL lipids (VLDL-C, VLDL-TG, VLDL-PL, VLDL-apoB).
  • Ratios of VLDL lipids to VLDL apolipoprotein B were calculated as estimators of particle content.
  • Cox regression analyses examined associations with 1-year mortality in 315 AHF patients.

Main Results:

  • A significant inverse association was found between VLDL-C/VLDL-apoB, VLDL-TG/VLDL-apoB, and VLDL-PL/VLDL-apoB and 1-year mortality.
  • VLDL-C/VLDL-apoB remained a significant independent predictor of mortality after adjusting for clinical and laboratory parameters.
  • 118 (37.5%) of AHF patients died within 1 year.

Conclusions:

  • The cholesterol content of circulating VLDL particles (VLDL-C/VLDL-apoB) may serve as a valuable prognostic marker in acute heart failure.
  • Further research into VLDL composition could enhance risk stratification for AHF patients.

Keywords:
NMR spectroscopyacute heart failurecholesterolmortalityprognostic biomarkersriskvery-low-density lipoprotein

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