Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abdominal operations: effect on subsequent experimental faecal peritonitis.

S M Almdahl, B Osterud

    Scandinavian Journal of Gastroenterology
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Plasma vitamin D levels and inflammation in the aortic wall of patients with coronary artery disease with and without inflammatory rheumatic disease.

    Scandinavian journal of rheumatology·2016
    Same author

    The key roles of complement and tissue factor in Escherichia coli-induced coagulation in human whole blood.

    Clinical and experimental immunology·2015
    Same author

    Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide-stimulated monocytes.

    Journal of thrombosis and haemostasis : JTH·2015
    Same author

    Alterations in markers of coagulation and fibrinolysis in patients with Paroxysmal Nocturnal Hemoglobinuria before and during treatment with eculizumab.

    Thrombosis research·2015
    Same author

    Circadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatonin.

    Spinal cord·2015
    Same author

    One-stage coronary, carotid, aortobifemoral, and femoropoliteal surgery for concomitant critical ischemia in three vascular beds.

    The Journal of cardiovascular surgery·2014
    Same journal

    Assessing trial eligibility and real-world response to vedolizumab and ustekinumab in patients with ulcerative colitis.

    Scandinavian journal of gastroenterology·2026
    Same journal

    M2 macrophage activation in recurrent acute pancreatitis: an explorative analysis of a randomized controlled trial.

    Scandinavian journal of gastroenterology·2026
    Same journal

    Safety and performance of small bowel capsule endoscopy in patients with surgically altered gastrointestinal anatomy.

    Scandinavian journal of gastroenterology·2026
    Same journal

    Textbook outcome after esophagectomy in Norway - a national cohort study of low- to medium-volume centers.

    Scandinavian journal of gastroenterology·2026
    Same journal

    Fecal calprotectin concentration in adults with and without <i>Helicobacter pylori</i> infection.

    Scandinavian journal of gastroenterology·2026
    Same journal

    Endoloop-clip closure versus hemoclips for large sigmoid colon perforations: a randomized controlled <i>ex vivo</i> study.

    Scandinavian journal of gastroenterology·2026
    See all related articles

    Abdominal surgery, particularly with minor infection, enhances rats' tolerance to subsequent peritonitis. This improved survival may be due to stimulated leukocytes, including macrophages and neutrophils, responding more effectively.

    Area of Science:

    • Immunology
    • Surgical Science
    • Gastroenterology

    Background:

    • Peritonitis is a serious abdominal infection.
    • The immune response to abdominal surgery and infection is complex.
    • Previous studies have not fully elucidated the role of leukocytes in post-operative peritonitis tolerance.

    Purpose of the Study:

    • To investigate the effect of abdominal operations on subsequent peritonitis tolerance in rats.
    • To determine the role of peritoneal leukocytes in mediating this tolerance.

    Main Methods:

    • Rats underwent laparotomy, anesthesia only, laparotomy with ileum isolation, or no treatment.
    • Animals were challenged with endogenous fecal peritonitis 1-2 weeks post-operation.
    • Peritoneal lavage fluid was analyzed for leukocyte counts (macrophages, neutrophils).

    Related Experiment Videos

    Main Results:

    • Survival rates were 40% for laparotomy and 100% for ileum isolation groups, versus 0% for controls.
    • Peritoneal leukocyte counts, especially macrophages and neutrophils, were significantly higher in the laparotomy group.
    • Ileum isolation conferred complete protection against subsequent peritonitis.

    Conclusions:

    • Abdominal operations, especially with a minor infectious challenge, increase tolerance to subsequent peritonitis.
    • This enhanced tolerance is potentially mediated by previously stimulated and sensitized peritoneal leukocytes.
    • Ileum isolation significantly improves survival, suggesting a protective immune mechanism.