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Related Experiment Video

Updated: Aug 23, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Thyroid Cancer and Psoriasis: A Nested Case-Control Study.

So Young Kim¹, Dae Myoung Yoo², Juyong Chung³

¹Bundang CHA Medical Center, Department of Otorhinolaryngology-Head and Neck Surgery, CHA University, Seongnam 13488, Korea.

Diagnostics (Basel, Switzerland)

|October 27, 2022

Summary

Psoriasis is not linked to thyroid cancer risk in adults overall. However, younger adults and those without hypothyroidism showed an increased risk of thyroid cancer when they also had psoriasis.

Keywords:

cohort studies psoriasis risk factors thyroid cancer

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Area of Science:

Epidemiology
Oncology
Dermatology

Background:

Previous studies suggest a possible link between psoriasis and an increased risk of thyroid cancer (TC), but findings are inconsistent.
Understanding this association is crucial for patient risk stratification and management.

Purpose of the Study:

To investigate the association between psoriasis and the risk of developing thyroid cancer in an adult population.
To explore potential modifying factors, such as age and thyroid status, on this relationship.

Main Methods:

A large cohort study using data from the Korean National Health Insurance Service—Health Screening Cohort (≥ 40 years old).
Propensity score matching with overlap weighting was used to create comparable groups of TC patients (n=6822) and controls (n=27,288).
Multivariable logistic regression analysis assessed the association between psoriasis history and TC, with secondary analyses in various subgroups.

Main Results:

Overall, psoriasis was not significantly associated with an increased risk of TC (overlap-weighted OR = 1.02, 95% CI = 0.85−1.22).
A significant association was observed in adults younger than 55 years (OR = 1.69, 95% CI = 1.22−2.36).
Individuals without hypothyroidism showed an elevated TC risk with psoriasis (OR = 1.29, 95% CI = 1.06−1.57), while those with hypothyroidism had a reduced risk (OR = 0.59, 95% CI = 0.37−0.96).

Conclusions:

Psoriasis is not a risk factor for thyroid cancer in the general adult population.
Specific subgroups, namely younger adults and individuals without hypothyroidism, may experience an elevated risk of thyroid cancer in the presence of psoriasis.
Further research is warranted to elucidate the mechanisms underlying these subgroup-specific associations.