Related Experiment Video
Updated: Aug 19, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
Risk factors in schizophrenia: the Stony Brook High-Risk Project
Insights
Children with a schizophrenic parent exhibit significant cognitive and social impairments. Environmental factors like family conflict predict psychopathology, highlighting the need for early intervention in high-risk families.
Area of Science:
- Child and Adolescent Psychiatry
- Developmental Psychology
- Behavioral Genetics
Background:
- Identifying early risk factors for psychopathology is crucial for timely intervention.
- Family environment and parental mental health significantly influence child development.
- Understanding precursor patterns can aid in predicting and preventing serious mental disorders.
Purpose of the Study:
- To identify precursor patterns, environmental stressors, and protective factors for psychopathology.
- To assess the differential predictive value of these factors in high-risk children.
- To examine the long-term impact of parental mental illness on child adjustment.
Main Methods:
- Longitudinal study of 544 children (aged 7-15) from families with parental schizophrenia, bipolar disorder, unipolar depression, or no parental illness.
- Assessment of parental psychological functioning, family environment (conflict, parenting), and child adjustment.
- Measurement of early signs of psychopathology, including cognitive slippage and attentional deficits.
Main Results:
- Deviant family functioning (conflict, marital discord) was linked to poorer child adjustment.
- Children with a schizophrenic parent displayed extensive cognitive, attentional, and social impairments.
- At follow-up, 22.8% of children with a schizophrenic parent received a DSM-III diagnosis versus 9.6% of controls.
Conclusions:
- Parental psychopathology and adverse family environments are significant risk factors for child psychopathology.
- Early identification of cognitive, attentional, and social impairments is vital in high-risk populations.
- Longitudinal data confirm increased risk for developing disorders in offspring of parents with severe mental illness.
Abstract:
The goals of the Stony Brook High-Risk Project are to identify precursor patterns, environmental stressors, and protective factors that are differentially predictive of psychopathology. In phase I we assessed 219 families and 544 children aged 7-15, including 31 families and 80 children with a schizophrenic parent, 70 families and 154 children with a unipolar depressed parent, 58 families and 134 children with a bipolar parent, and 60 normal control families with 176 children. A 3-year followup was conducted on 84 percent of the sample, and an additional followup is underway. Our data include measures of: (1) psychological functioning of the parents; (2) the environment, including family functioning, marital adjustment, and parenting practices; (3) child adjustment, including peer, or teacher, parent, and self-ratings; (4) early signs or precursors to the development of schizophrenia or affective disorder, including cognitive slippage, attentional deficits, hedonic capacity, depressogenic attributional styles, and subsyndromal affective patterns. Considerable deviance in family functioning, expressed in conflict, marital discord, and parenting skills, was characteristic of the families with an ill parent, and this discord was related to child adjustment. Children with a schizophrenic parent showed multiple and extensive cognitive, attentional, and social impairments, and at the 18+ followup, 22.8 percent of them compared with 9.6 percent of the normal controls were assigned a DSM-III diagnosis.
More Related Videos
13:08Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
07:31Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
Published on: May 15, 2020
Related Concept Videos
Psychosis and Antipsychotic Drugs: Overview
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Psychosis: Goals of Pharmacotherapy
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychological and Sociocultural Causes of Schizophrenia
Drug Therapy
Antianxiety Medications