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Updated: Aug 23, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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The Diagnostic and Therapeutic Role of Circular RNA HIPK3 in Human Diseases

Yanfei Feng1, Zitong Yang2, Bodong Lv3

  • 1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.

Diagnostics (Basel, Switzerland)
|October 27, 2022
PubMed

Insights

Circular RNAs (circRNAs) regulate gene expression and impact human diseases. This review details the functions of circular homeodomain-interacting protein kinase 3 (circHIPK3) and its diagnostic and therapeutic potential.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are noncoding RNAs with a unique closed-loop structure.
  • Emerging evidence highlights their crucial roles in gene expression regulation and biological processes.
  • Circular homeodomain-interacting protein kinase 3 (circHIPK3) is a notable circRNA of significant research interest.

Purpose of the Study:

  • To provide a detailed description of circHIPK3 functions.
  • To comprehensively review the diagnostic and therapeutic value of circHIPK3.
  • To explore the role of circHIPK3 in various human diseases.

Main Methods:

  • Literature review of studies on circHIPK3.
  • Analysis of research on circHIPK3's involvement in biological processes.
  • Synthesis of data on circHIPK3's impact on disease development.

Main Results:

  • circHIPK3 plays a pivotal role in multiple biological processes.
  • circHIPK3 is implicated in the pathogenesis of cancers, cardiovascular diseases, diabetes mellitus, and inflammatory diseases.
  • circHIPK3 exhibits potential as a diagnostic biomarker and therapeutic target.

Conclusions:

  • circHIPK3 is a significant circRNA with diverse functions.
  • circHIPK3 holds promise for clinical applications in diagnosing and treating various diseases.
  • Further research into circHIPK3 mechanisms and applications is warranted.

Keywords:
circHIPK3circRNAshuman diseases

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