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Systemic Inflammation Is Associated with Pulmonary Hypertension in Isolated Giant Omphalocele: A Population-Based

Baptiste Teillet1, Mohamed Riadh Boukhris1,2, Rony Sfeir2,3

  • 1Department of Neonatology, Pôle Femme-Mère-Nouveau-Né, Hôpital Jeanne de Flandre, Centre Hospitalier Universitaire de Lille, F-59000 Lille, France.

Healthcare (Basel, Switzerland)
|October 27, 2022
PubMed

Insights

A prolonged inflammatory state, marked by elevated CRP, platelets, and white blood cells, is linked to pulmonary hypertension (PH) in infants with giant omphaloceles (GO) undergoing delayed closure. This finding offers insights into PH development in this patient group.

Area of Science:

  • Pediatric Surgery
  • Neonatology
  • Cardiology

Background:

  • Giant omphalocele (GO) is a complex congenital anomaly requiring specialized management.
  • Pulmonary hypertension (PH) is a serious complication in neonates, particularly those with congenital defects.
  • The relationship between perinatal factors and PH development in isolated GO is not well understood.

Purpose of the Study:

  • To identify perinatal factors associated with the development of pulmonary hypertension (PH) in infants with isolated giant omphaloceles (GO).
  • To compare postnatal morbidities between infants with GO who developed PH and those who did not.

Main Methods:

  • Retrospective review of infants with omphalocele treated at the University Hospital of Lille (1996-2021).
  • Inclusion criteria: isolated GO involving liver, treated with delayed surgical closure.
  • Comparison of prenatal/postnatal data and morbidities between GO infants with and without PH.

Main Results:

  • 30% incidence of PH observed in 50 infants with isolated GO.
  • Prolonged inflammatory state (CRP > 15 mg/L, platelets > 500 G/L, WBC > 15 G/L for >14 days) was significantly more frequent in infants with PH (73% vs. 21%, p < 0.05).
  • No significant difference in late-onset infection rates between groups.

Conclusions:

  • A prolonged inflammatory syndrome appears to be a significant contributor to PH development in infants with isolated GO managed with delayed surgical closure.
  • Monitoring inflammatory markers may be crucial for early detection and management of PH in this vulnerable population.

Keywords:
delayed surgical closuregiant omphalocele (GO)inflammatory syndromenewborn infantpulmonary hypertension

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