Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biomaterial-centered infection: microbial adhesion versus tissue integration.

A G Gristina

    Science (New York, N.Y.)
    |September 25, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A standardized method for the assessment of shoulder function.

    Journal of shoulder and elbow surgery·2012
    Same author

    A novel spinal implant infection model in rabbits.

    Spine·2000
    Same author

    Biomaterial-induced dysfunction in the capacity of rabbit alveolar macrophages to kill Staphylococcus epidermidis RP12.

    Journal of biomedical materials research·1995
    Same author

    Simple technique for the preparation of silicone gel particles: the effect of silicone gel particles on oxidative responses of macrophages.

    Journal of biomedical materials research·1995
    Same author

    Inhibition of Staphylococcus adherence to biomaterials by extracellular slime of S. epidermidis RP12.

    Journal of biomedical materials research·1994
    Same author

    The glycocalyx, biofilm, microbes, and resistant infection.

    Seminars in arthroplasty·1994

    Biomaterials for tissue substitution face challenges like bacterial infection and poor tissue integration. Surface modifications at the atomic level can enhance compatibility and prevent infections.

    Area of Science:

    • Biomaterials science
    • Biomedical engineering
    • Microbiology
    • Biochemistry
    • Physics

    Background:

    • Biomaterials are increasingly used for tissue substitution in complex devices like artificial joints and hearts.
    • Key challenges include bacterial adhesion leading to biomaterial-centered infections and inadequate tissue integration.
    • Cellular interactions with biomaterials depend on surface atomic geometry and electronic states.

    Purpose of the Study:

    • To understand the mechanisms of biomaterial-bacteria and biomaterial-tissue cell interactions.
    • To explore how atomic-level surface modifications can improve biomaterial performance.
    • To reduce infection and enhance tissue compatibility for medical devices.

    Main Methods:

    Related Experiment Videos

    • Investigating the role of atomic geometry and electronic states in biomaterial surface interactions.
    • Analyzing bacterial adhesion mechanisms on biomaterial surfaces.
    • Examining tissue cell integration with various biomaterial substrates.

    Main Results:

    • Biomaterial surface properties at the atomic level significantly influence bacterial adhesion and tissue cell interactions.
    • Understanding these interactions is crucial for developing advanced medical implants.
    • Surface modifications can be tailored to control cellular responses.

    Conclusions:

    • Atomic-level surface engineering of biomaterials is key to overcoming current limitations.
    • This approach can program cell-to-substratum events, enhancing tissue integration.
    • Strategic modifications can diminish bacterial adhesion, reducing infection risk and improving device longevity.