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Intersection of the Ubiquitin-Proteasome System with Oxidative Stress in Cardiovascular Disease

Min Qiu1,2, Jimei Chen1,2, Xiaohong Li1

  • 1Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

International Journal of Molecular Sciences
|October 27, 2022
PubMed

Insights

Cardiovascular diseases (CVDs) involve oxidative stress and the ubiquitin-proteasome system (UPS). Understanding their combined role in CVDs offers new therapeutic targets.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) are a leading global health issue with high incidence and mortality.
  • Oxidative stress is a key mediator in numerous CVD pathophysiological mechanisms.
  • The ubiquitin-proteasome system (UPS), crucial for protein degradation and cellular repair, is increasingly implicated in CVD development.

Purpose of the Study:

  • To review recent research on the individual and combined roles of the ubiquitin-proteasome system (UPS) and oxidative stress in cardiovascular diseases (CVDs).
  • To elucidate the mechanisms underlying UPS-mediated oxidative stress in CVD pathophysiology.
  • To explore the contribution of these interactions across different stages of key CVDs.

Main Methods:

  • Literature review synthesizing current research findings.
  • Focus on the pathophysiology of atherosclerosis, ischemia-reperfusion injury, cardiomyopathy, and heart failure.
  • Analysis of the interplay between UPS function, oxidative stress, and redox homeostasis.

Main Results:

  • Oxidative stress is a central player in CVD pathogenesis.
  • UPS dysfunction is linked to the development and progression of CVDs.
  • The interaction between UPS and oxidative stress influences cellular homeostasis and disease states.

Conclusions:

  • The combined actions of the UPS and oxidative stress are critical in the pathophysiology of various cardiovascular diseases.
  • Further research into the UPS-oxidative stress axis is warranted to understand disease mechanisms.
  • Targeting the UPS-oxidative stress interaction presents novel therapeutic strategies for CVD prevention and treatment.

Keywords:
cardiovascular diseasesoxidative stressubiquitin–proteasome system

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