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Updated: Aug 23, 2025

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
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Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of

Stephen M Stahl1,2, Sara De Martin3, Andrea Mattarei3

  • 1Department of Psychiatry, VAMC (SD), University of California, La Jolla, San Diego, CA 92093, USA.

International Journal of Molecular Sciences
|October 27, 2022
PubMed

Keywords:
N-methyl-D-aspartate receptorREL-1017d-methadonedepressiondextromethorphanesketamineesmethadoneketaminemajor depressive disorderneural plasticity

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