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Updated: Aug 23, 2025

Isolating Intestinal Stem Cells from Adult Drosophila Midguts by FACS to Study Stem Cell Behavior During Aging
Published on: December 16, 2014
Wnt Signaling and Aging of the Gastrointestinal Tract
Naoki Asano1, Akio Takeuchi1, Akira Imatani1
1Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Abstract:
Aging is considered a risk factor for various diseases including cancers. In this aging society, there is an urgent need to clarify the molecular mechanisms involved in aging. Wnt signaling has been shown to play a crucial role in the maintenance and differentiation of tissue stem cells, and intensive studies have elucidated its pivotal role in the aging of neural and muscle stem cells. However, until recently, such studies on the gastrointestinal tract have been limited. In this review, we discuss recent advances in the study of the role of Wnt signaling in the aging of the gastrointestinal tract and aging-related carcinogenesis.
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