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Percutaneous organophosphate poisoning.

A Halle, D D Sloas

    Southern Medical Journal
    |September 1, 1987
    PubMed
    Summary

    Organophosphate insecticide Diazinon, used for pubic lice, caused poisoning symptoms including seizure. Empiric treatment with pralidoxime and atropine led to complete recovery, highlighting prompt intervention for organophosphate poisoning.

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    Area of Science:

    • Toxicology
    • Dermatology
    • Emergency Medicine

    Background:

    • Organophosphate insecticides are widely used but pose significant toxicity risks.
    • Cutaneous exposure can lead to systemic absorption and poisoning.
    • Pubic lice infestations are typically treated with topical agents.

    Observation:

    • A patient developed cholinergic excess, loss of consciousness, and seizure after applying the organophosphate insecticide Diazinon to the skin for pubic lice.
    • Clinical suspicion for organophosphate poisoning was high due to the severity of symptoms.

    Findings:

    • The patient received empiric therapy with pralidoxime and atropine.
    • The treatment was effective, leading to a complete recovery.

    Implications:

    • This case underscores the potential for severe systemic toxicity from topical organophosphate use, even for conditions like pubic lice.
    • Prompt administration of specific antidotes like pralidoxime and atropine is crucial for managing organophosphate poisoning.
    • Healthcare providers should be aware of the risks associated with off-label or inappropriate use of insecticides.

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