Related Experiment Video
Updated: Aug 7, 2026

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
Published on: January 7, 2015
Severe neutropenia due to sustained-release procainamide
Abstract:
With increased use of sustained-release forms of procainamide in treating common cardiac arrhythmias, more and more cases of severe neutropenia and occasional deaths have been reported. It is unclear whether all sustained-release procainamide preparations are implicated. I recommend that a complete blood count be done every two weeks for the first three months of treatment with these drugs. Any patient who has an unexplained fever or a toxic reaction while taking one of these preparations should have a complete blood count done.
Related Concept Videos
Desensitization and Tachyphylaxis
Several...
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Drug Toxicity: Dose-Dependent Reactions
Drug toxicity: Idiosyncratic Reactions
