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CPAP Influence on Readily Available Inflammatory Markers in OSA-A Pilot Study
Ioana Madalina Zota1, Cristina Andreea Adam1, Dragoș Traian Marius Marcu1
1Department of Medical Specialties (I), Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iași, Romania.
International Journal of Molecular Sciences
|October 27, 2022
Summary
Simple blood tests can help identify moderate-to-severe obstructive sleep apnea (OSA). These inflammatory markers predict OSA presence but are not significantly changed by short-term CPAP treatment.
Area of Science:
- Sleep Medicine
- Cardiology
- Pulmonology
Background:
- Obstructive sleep apnea (OSA) involves airway collapse, hypoxia, and inflammation.
- Inflammatory biomarkers are increasingly recognized for their role in OSA pathogenesis.
Purpose of the Study:
- To assess common inflammatory markers for predicting moderate-to-severe OSA.
- To evaluate the impact of CPAP therapy on these biomarkers.
Main Methods:
- Prospective study of patients with newly diagnosed moderate-severe OSA.
- Comparison with control groups (no OSA, mild OSA).
- Analysis of C-reactive protein (CRP), ESR, WBC, RDW, NLR, PLR, MPV, WMR, and LCR before and after 8 weeks of CPAP.
Main Results:
- CRP, ESR, NLR, and WMR correlated with OSA severity.
- Weight status decreased significantly after 8-week CPAP therapy.
- Short-term CPAP did not significantly alter the studied inflammatory parameters.
Conclusions:
- Readily available inflammatory markers can predict moderate-to-severe OSA.
- These biomarkers are not significantly influenced by short-term CPAP treatment.
- Further research may explore their role in OSA management.
Keywords:
C-reactive protein (CRP)continuous positive airway pressure (CPAP)inflammationneutrophil-to-lymphocyte ratio (NLR)obstructive sleep apnea (OSA)platelet-to-lymphocyte ratio (PLR)red cell distribution width (RDW)More Related Videos
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