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Insights into Carbapenem Resistance in Vibrio Species: Current Status and Future Perspectives

Joanna Xuan Hui Goh1, Loh Teng-Hern Tan1,2, Jodi Woan-Fei Law1

  • 1Novel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor Darul Ehsan 47500, Malaysia.

International Journal of Molecular Sciences
|October 27, 2022
PubMed

Insights

Environmental Vibrio species may act as hidden vectors for carbapenem resistance. Understanding their role is crucial for developing strategies against antimicrobial resistance.

Area of Science:

  • Environmental microbiology
  • Antimicrobial resistance
  • Molecular biology

Background:

  • Carbapenem resistance is a growing global health concern, as carbapenems are last-resort antibiotics.
  • While antibiotic overuse drives resistance, non-clinical microbial strains are increasingly found to harbor carbapenemase genes.
  • Environmental microbial populations may act as reservoirs and disseminators of carbapenem resistance.

Purpose of the Study:

  • To investigate the carbapenem resistance profiles of Vibrio species in various environments.
  • To identify factors contributing to the spread of carbapenem resistance traits.
  • To elucidate the transmission pathways of carbapenem resistance.

Main Methods:

  • Literature review and data synthesis on Vibrio species and carbapenem resistance.
  • Analysis of environmental sampling data related to Vibrio.
  • Genomic and phenotypic characterization of carbapenemase genes in Vibrio.

Main Results:

  • Vibrio species harbor diverse carbapenemase genes, indicating environmental dissemination.
  • Environmental factors and mobile genetic elements facilitate the spread of resistance.
  • Specific Vibrio species show potential as indicator organisms for environmental carbapenem resistance.

Conclusions:

  • Vibrio species play a significant role in the environmental spread of carbapenem resistance.
  • Understanding resistance mechanisms in Vibrio is key to developing effective antimicrobial stewardship.
  • Environmental surveillance of Vibrio can aid in predicting and controlling carbapenem resistance.
Keywords:
Vibrioantibioticsantimicrobialcarbapenemenvironmentalindicator strainmechanismresistance

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