Related Experiment Video
Updated: Aug 23, 2025
05:12
Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
Published on: September 4, 2017
11.0K
Dysregulated Hemostasis and Immunothrombosis in Cerebral Cavernous Malformations
Maria Ascencion Globisch1, Favour Chinyere Onyeogaziri1, Ross Osborne Smith1
1Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.
International Journal of Molecular Sciences
|October 27, 2022
Summary
Cerebral cavernous malformations (CCM) are increasingly viewed as a hemostatic disease. Research highlights the role of blood components and neuroinflammation in CCM development and severity, suggesting new therapeutic avenues.
Area of Science:
- Neuroscience
- Vascular Biology
- Hematology
Background:
- Cerebral cavernous malformation (CCM) affects 0.5% of the population.
- Historically, CCM research focused on genetic mutations and endothelial cell biology.
- Recent studies reveal crucial roles for the hemostatic system and neuroinflammation in CCM.
Purpose of the Study:
- To review the latest molecular insights into CCM pathogenesis.
- To explore the interaction between CCM-deficient endothelial cells, blood components, and the neurovascular unit.
- To underscore the link between endothelial dysfunction and CCM-related symptoms.
Main Methods:
- Comprehensive literature review.
- Analysis of transcriptome and proteome studies.
- Focus on molecular mechanisms and clinical implications.
Main Results:
- Endothelial dysfunction in CCM leads to dysregulated hemostasis.
- Bleeding, hypoxia, and neurological symptoms are linked to endothelial dysfunction.
- CCM is increasingly recognized as a disease involving the hemostatic system.
Conclusions:
- CCM pathogenesis involves complex interactions between endothelial cells and blood components.
- The hemostatic system plays a critical role in CCM development and severity.
- Viewing CCM as a hemostatic disease may open new therapeutic strategies.
Related Concept Videos
01:24Disorders of Hemostasis
1.1K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.1K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
849
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
849
01:30Venous Thrombosis I: Introduction
26
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
26
00:49The Blood-brain Barrier
48.0K
Overview
48.0K
01:16Clot Retraction and Fibrinolysis
6.7K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.7K
01:29Venous Thrombosis III: Interprofessional Care
18
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
18