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Huiling Wang1, Mingfang Wang1, Zefeng Nie1

  • 1Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, School of Chemistry, Central China Normal University, Wuhan 430079, China.

International Journal of Molecular Sciences
|October 27, 2022
PubMed

Keywords:
DNAHADDOCK dockingSAXSSOD1redox-dependent binding

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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...