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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
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Choroidal Melanocytic Hamartoma
Ramesh Venkatesh1, Sameeksha Agrawal1, Nikitha Gurram Reddy1
1Narayana Nethralaya, Department of Retina and Vitreous, #121/C, Chord Road, 1st R Block Rajaji Nagar, Bangalore 560010, India.
Journal of Clinical Medicine
|October 27, 2022
Summary
New research identifies a distinct choroidal lesion, termed choroidal melanocytic hamartoma, visible on advanced imaging like MultiColor® imaging and optical coherence tomography (OCT) but not on standard clinical exams. Further follow-up is needed to confirm its benign nature.
Area of Science:
- Ophthalmology
- Medical Imaging
- Histopathology
Background:
- Flat, choroidal lesions can be challenging to detect with conventional methods.
- Advanced imaging techniques offer new possibilities for visualizing subtle ocular pathologies.
Purpose of the Study:
- To characterize a distinct type of flat, choroidal lesion identified through advanced imaging.
- To propose a new clinical entity based on distinct imaging and clinical features.
Main Methods:
- Observational case series involving 12 eyes from 11 patients.
- Utilized MultiColor® (MCI) imaging, optical coherence tomography (OCT), and conventional color fundus photography.
- Compared imaging findings with clinical examination and known ocular entities.
Main Results:
- Distinct orange-colored lesions were observed on MCI, difficult to discern on color fundus images.
- OCT revealed flat, homogeneous, hyperreflective choroidal lesions with intact overlying retinal layers.
- Lesions showed characteristics consistent with the presence of melanin, leading to the name 'choroidal melanocytic hamartoma'.
Conclusions:
- A novel clinical entity, 'choroidal melanocytic hamartoma,' has been identified.
- This lesion is characterized by specific findings on MCI and OCT, distinguishing it from other conditions.
- Longer follow-up is necessary to establish the benign nature of this newly described hamartoma.
