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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Choroidal Melanocytic Hamartoma.

Ramesh Venkatesh¹, Sameeksha Agrawal¹, Nikitha Gurram Reddy¹

¹Narayana Nethralaya, Department of Retina and Vitreous, #121/C, Chord Road, 1st R Block Rajaji Nagar, Bangalore 560010, India.

Journal of Clinical Medicine

|October 27, 2022

Summary

This summary is machine-generated.

New research identifies a distinct choroidal lesion, termed choroidal melanocytic hamartoma, visible on advanced imaging like MultiColor® imaging and optical coherence tomography (OCT) but not on standard clinical exams. Further follow-up is needed to confirm its benign nature.

Keywords:

choroid hamartoma melanin multimodal imaging

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Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Published on: May 26, 2023

Area of Science:

Ophthalmology
Medical Imaging
Histopathology

Background:

Flat, choroidal lesions can be challenging to detect with conventional methods.
Advanced imaging techniques offer new possibilities for visualizing subtle ocular pathologies.

Purpose of the Study:

To characterize a distinct type of flat, choroidal lesion identified through advanced imaging.
To propose a new clinical entity based on distinct imaging and clinical features.

Main Methods:

Observational case series involving 12 eyes from 11 patients.
Utilized MultiColor® (MCI) imaging, optical coherence tomography (OCT), and conventional color fundus photography.
Compared imaging findings with clinical examination and known ocular entities.

Main Results:

Distinct orange-colored lesions were observed on MCI, difficult to discern on color fundus images.
OCT revealed flat, homogeneous, hyperreflective choroidal lesions with intact overlying retinal layers.
Lesions showed characteristics consistent with the presence of melanin, leading to the name 'choroidal melanocytic hamartoma'.

Conclusions:

A novel clinical entity, 'choroidal melanocytic hamartoma,' has been identified.
This lesion is characterized by specific findings on MCI and OCT, distinguishing it from other conditions.
Longer follow-up is necessary to establish the benign nature of this newly described hamartoma.