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Bronchial Asthma and Sarcopenia: An Upcoming Potential Interaction
Nikolaos D Karakousis1, Ourania S Kotsiou2,3, Konstantinos I Gourgoulianis3
1Primary Healthcare, Internal Medicine Department, Amarousion, 15125 Athens, Greece.
Journal of Personalized Medicine
|October 27, 2022
Summary
Sarcopenia, or low muscle mass, is linked to reduced lung function and increased mortality in asthma patients. Pulmonologists should screen asthmatics for sarcopenia to improve patient outcomes.
Area of Science:
- Pulmonology
- Gerontology
- Metabolic Diseases
Background:
- Sarcopenia, the progressive loss of skeletal muscle mass, is a growing global health concern.
- Asthma affects about 8% of adults worldwide as a chronic inflammatory respiratory condition.
- Limited data exist on the interplay between sarcopenia and asthma.
Purpose of the Study:
- To investigate the potential association between sarcopenia and asthma.
- To explore the bidirectional impact of sarcopenia and asthma on patient health outcomes.
Main Methods:
- A systematic literature search was conducted across PubMed, Scopus, MEDLINE, and Google Scholar.
- Three original English-language studies were included in the analysis.
- References of identified articles were reviewed, and animal studies were excluded.
Main Results:
- Prevalence of sarcopenia in asthmatics ranges from 2% to 17% in existing literature.
- Asthmatic patients with sarcopenia exhibit diminished lung function and potentially elevated mortality risk.
- Asthma-COPD overlap syndrome with sarcopenia may increase risks of osteopenia, osteoporosis, fractures, and disability.
Conclusions:
- Emerging evidence suggests a significant link between sarcopenia and asthma.
- Pulmonologists should consider sarcopenia screening in asthma patients.
- Early identification and management of sarcopenia may mitigate adverse outcomes in asthma.
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