Multifunctional Microspheres Based on D-Mannose and Resveratrol for Ciprofloxacin Release

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Nanotechnology

Background:

• Developing advanced drug delivery systems is crucial for effective treatment of infections.
• Microspheres offer a versatile platform for controlled drug release.
• Combining antimicrobial and antioxidant properties in a single delivery system enhances therapeutic outcomes.

Purpose of the Study:

• To prepare and characterize novel functional microspheres using D-mannose and resveratrol.
• To evaluate the drug loading, release kinetics, and antibacterial activity of ciprofloxacin-loaded microspheres.
• To assess the antioxidant efficacy of the developed microspheres.

Main Methods:

• Microsphere preparation via esterification of D-mannose and resveratrol derivatives.
• Characterization using light scattering, FT-IR spectrophotometry, and scanning electron microscopy (SEM).
• In vitro drug release studies at different pH values (1.2, 6.8, 7.4), antibacterial assays against Escherichia coli, and antioxidant activity tests.

Main Results:

• High encapsulation efficiency (100%) of ciprofloxacin achieved.
• Significant drug release observed: 55% at pH 6.8 and 99% at pH 7.4.
• Demonstrated potent antibacterial activity against Escherichia coli and confirmed antioxidant efficacy.

Conclusions:

• D-mannose and resveratrol-based microspheres are effective multifunctional vectors for ciprofloxacin delivery.
• These microspheres show promise for treating intestinal and urinary tract infections.
• The combination of antimicrobial and antioxidant properties offers a synergistic therapeutic approach.