Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia01:30

Dementia

155
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
155
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

626
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
626
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

246
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
246

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Guidelines for Qualifications of Neurodiagnostic Personnel: A Joint Position Statement of the American Clinical Neurophysiology Society, the American Association of Neuromuscular & Electrodiagnostic Medicine, the American Society of Neurophysiological Monitoring, and ASET The Neurodiagnostic Society.

Muscle & nerve·2023
Same author

Guidelines for Qualifications of Neurodiagnostic Personnel: A Joint Position Statement of the American Clinical Neurophysiology Society, the American Association of Neuromuscular & Electrodiagnostic Medicine, the American Society of Neurophysiological Monitoring, and ASET - The Neurodiagnostic Society.

The Neurodiagnostic journal·2023
Same author

Guidelines for Qualifications of Neurodiagnostic Personnel: A Joint Position Statement of the American Clinical Neurophysiology Society, the American Association of Neuromuscular & Electrodiagnostic Medicine, the American Society of Neurophysiological Monitoring, and ASET-The Neurodiagnostic Society.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2023
Same author

Dementia and Diet, Methodological and Statistical Issues: A Pilot Study.

Frontiers in aging neuroscience·2022
Same author

American Clinical Neurophysiology Society Guideline 5: Minimum Technical Standards for Pediatric Electroencephalography.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2016
Same author

Effects of insulin on peripheral nerves.

Journal of diabetes and its complications·2016
Same journal

Correction: Iliuta et al. Impact of Pulmonary Hypertension on Mortality After Surgery for Aortic Stenosis. <i>Medicina</i> 2022, <i>58</i>, 1231.

Medicina (Kaunas, Lithuania)·2026
Same journal

Prognostic Value of BUN-Based Ratios for Mortality and Prolonged Hospitalization in Acute Upper Gastrointestinal Bleeding: Comparison with Established Risk Scores.

Medicina (Kaunas, Lithuania)·2026
Same journal

One-Year Comparative Outcomes of Conventional Versus Accelerated Corneal Cross-Linking in Progressive Keratoconus.

Medicina (Kaunas, Lithuania)·2026
Same journal

Beyond the Intestinal Mucosa in Long-Standing Inflammatory Bowel Disease: Consequences of Chronic Inflammation and Endoscopic Approaches to Diagnosis and Management.

Medicina (Kaunas, Lithuania)·2026
Same journal

Biological and Metabolic Correlates of Psychological Resilience in Maintenance Hemodialysis: An Exploratory Gender-Based Study.

Medicina (Kaunas, Lithuania)·2026
Same journal

Influence of Mitral Annular Calcification Assessed by Cardiac Computed Tomography on Procedural and Clinical Outcomes of Transcatheter Aortic Valve Implantation.

Medicina (Kaunas, Lithuania)·2026
See all related articles

Related Experiment Video

Updated: Aug 23, 2025

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.4K

A Perspective: Challenges in Dementia Research.

Mark Stecker1

  • 1Fresno Institute of Neuroscience, Fresno, CA 93720, USA.

Medicina (Kaunas, Lithuania)
|October 27, 2022
PubMed
Summary
This summary is machine-generated.

Finding effective dementia treatments requires a major shift. The paper proposes transforming small research projects into large, collaborative multinational efforts to overcome current challenges in dementia research.

Keywords:
Alzheimer’s diseasebig databiomarkersdementiaimagingneurophysiology

More Related Videos

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.1K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.7K

Related Experiment Videos

Last Updated: Aug 23, 2025

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.4K
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.1K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.7K

Area of Science:

  • Neuroscience
  • Gerontology
  • Clinical Medicine

Background:

  • Dementia is a prevalent and severe condition with over a century of research yielding no disease-modifying treatments.
  • The current research landscape faces significant hurdles in developing effective therapies for dementia.

Purpose of the Study:

  • To present a clinician's perspective on critical challenges in dementia research.
  • To identify specific targets for discussion, criticism, and future research in the field of dementia.

Main Methods:

  • The paper offers a perspective based on current research and clinical experience.
  • It highlights the need for a paradigm shift in research methodology and collaboration.

Main Results:

  • A key challenge is the fragmentation of research into small, isolated projects.
  • The need for a transition towards large-scale, multinational research projects is emphasized.

Conclusions:

  • Transforming dementia research requires integrating clinicians and researchers into multinational projects.
  • Collaboration among researchers, industry, regulatory bodies, and the public, alongside financial investment, is crucial for progress.