Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

780
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
780
Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

577
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
577
Membrane Transporters01:31

Membrane Transporters

12.2K
Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
Transporters are mainly composed of alpha-helices, built from bundles of ten or more helices traversing the plasma membrane. The solute-binding sites are located midway, where some of the helices are broken or distorted, making space for the binding site through...
12.2K
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

248
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
248
Drug Absorption Mechanism: Passive Membrane Transport01:23

Drug Absorption Mechanism: Passive Membrane Transport

4.3K
Passive transport is a method of drug absorption where small, lipid-soluble drugs can move across the cell membrane. This movement happens along the concentration gradient, which is a natural flow from higher to lower concentration areas. The speed at which the drug moves is directly related to its lipid–water partition coefficient. This means that the more a drug dissolves in lipids, the faster it diffuses or spreads throughout the body. It is important to note that most drugs are either...
4.3K
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport01:19

Drug Absorption Mechanism: Carrier-Mediated Membrane Transport

4.0K
Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of anti-tuberculosis drugs on the pharmacokinetics and pharmacodynamics of novel antidiabetic drugs: A scoping review.

Pulmonology·2026
Same author

A multinational Delphi consensus on tuberculosis screening of migrants in Europe.

ERJ open research·2025
Same author

Unraveling the self-assembly and molecular interactions of a bio-inspired, vesicle-forming surfactant with block copolymers of varying hydrophobic/hydrophilic balance.

Journal of colloid and interface science·2025
Same author

European guidelines for the management of tuberculosis screening procedures in migrants: A systematic review.

Pulmonology·2025
Same author

Expert perspectives on tuberculosis screening procedures for migrants.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia·2025
Same author

Cationic Serine-Based Gemini Surfactant:Monoolein Aggregates as Viable and Efficacious Agents for DNA Complexation and Compaction: A Cytotoxicity and Physicochemical Assessment.

Journal of functional biomaterials·2024

Related Experiment Video

Updated: Aug 23, 2025

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

3.6K

Special Issue on Drug-Membrane Interactions Volume II.

Marina Pinheiro1, Sandra G Silva2

  • 1LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.

Membranes
|October 27, 2022
PubMed
Summary

Cell membranes are essential for all life, forming the fundamental boundary of every cell. This research explores the critical role of these cellular membranes in sustaining life.

More Related Videos

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

46.5K
Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers
07:18

Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers

Published on: January 16, 2019

9.7K

Related Experiment Videos

Last Updated: Aug 23, 2025

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
12:18

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

3.6K
Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

46.5K
Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers
07:18

Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers

Published on: January 16, 2019

9.7K

Area of Science:

  • Cell biology
  • Biochemistry
  • Biophysics

Background:

  • The cell membrane is a fundamental component of all living organisms.
  • It acts as a selective barrier, controlling the passage of substances into and out of the cell.
  • The integrity and function of the cell membrane are crucial for cellular processes.

Discussion:

  • This study emphasizes the indispensable nature of cell membranes for life's existence.
  • It highlights how membranes define cellular boundaries and compartmentalize functions.
  • The research underscores the evolutionary significance of membrane-bound structures.

Key Insights:

  • Cellular membranes are a prerequisite for life as we know it.
  • No known life forms exist without a cell membrane.
  • Membranes are central to cellular organization and function.

Outlook:

  • Further research into membrane biogenesis and evolution could reveal insights into the origins of life.
  • Understanding membrane dynamics may lead to novel therapeutic strategies.
  • Exploring extremophile cell membranes could expand our definition of life.