Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.5K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electric fields trigger ceramide-dependent vesicle budding and boost the generation of small extracellular vesicles.

Communications biology·2026
Same author

Role of lipid droplet-mediated lipid peroxidation by GPX4 in docosahexaenoic acid-induced EA.hy926 endothelial cell ferroptosis.

Biochimica et biophysica acta. Molecular and cell biology of lipids·2026
Same author

Differential migratory phenotypes of human neutrophils and breast cancer cells in a wireless unidirectional electric field platform.

Microsystems & nanoengineering·2026
Same author

Quantitative assessment of neutrophil chemotactic migration under coexisting intermediate and terminal chemokine gradients in a microfluidic environment: Applications for immune dysfunction and prognostic evaluation in sepsis.

Analytica chimica acta·2026
Same author

Modulation of lipid droplet biogenesis by p38 MAPK and caspase-1 in docosahexaenoic acid-induced EA.hy926 endothelial cell apoptosis.

Biochimica et biophysica acta. Molecular and cell biology of lipids·2025
Same author

A passive flow microreactor for urine creatinine test.

Microsystems & nanoengineering·2025

Related Experiment Video

Updated: Aug 23, 2025

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.0K

T Cells Chemotaxis Migration Studies with a Multi-Channel Microfluidic Device.

Yang Liu1, Xiaoou Ren1, Jiandong Wu2

  • 1Department of Physics and Astronomy, University of Manitoba, 30A Sifton Rd, 301 Allen Bldg, Winnipeg, MB R3T 2N2, Canada.

Micromachines
|October 27, 2022
PubMed
Summary

This study introduces a microfluidic device for precise T cell migration analysis. It enables real-time, quantitative assessment of immune cell movement and response to environmental cues.

Keywords:
T cellschemotaxismicrofluidic devicemigrationmulti-channel

More Related Videos

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.1K
Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration
06:42

Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration

Published on: May 24, 2024

1.6K

Related Experiment Videos

Last Updated: Aug 23, 2025

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.0K
Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.1K
Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration
06:42

Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration

Published on: May 24, 2024

1.6K

Area of Science:

  • Immunology
  • Cell Biology
  • Microfluidics

Background:

  • Immune surveillance relies on lymphocyte migration and recruitment.
  • Cell motility varies from random movement to directed chemotaxis.
  • Understanding T cell migration is crucial for immune response studies.

Purpose of the Study:

  • To describe a novel flow-based microfluidic device for quantitative cell migration assays.
  • To enable real-time investigation of T cell migratory responses.
  • To facilitate population and single-cell level analysis of immune cell motility.

Main Methods:

  • Development of a flow-based microfluidic device.
  • Performing quantitative multiplex cell migration assays.
  • Utilizing in situ fixation and direct fluorescence analysis within microchannels.

Main Results:

  • The device allows for real-time monitoring of T cell migration.
  • Quantitative data can be obtained at both population and single-cell levels.
  • In situ analysis enables direct fluorescence assessment of cell behavior.

Conclusions:

  • The microfluidic device provides a powerful tool for studying T cell migration.
  • This technology facilitates detailed investigation of immune cell chemotaxis and motility.
  • The system supports comprehensive analysis of immune surveillance mechanisms.