Related Experiment Video

Updated: Aug 23, 2025

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

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Human Papillomavirus Infection during Pregnancy and Childhood: A Comprehensive Review

Ali Ardekani1,2, Erfan Taherifard1, Abolfazl Mollalo3

  • 1School of Medicine, Shiraz University of Medical Sciences, Shiraz 73, Iran.

Microorganisms
|October 27, 2022
PubMed

Insights

Human papillomavirus (HPV) infection poses risks during pregnancy and infancy, with potential for cancer development. Vaccination is key to preventing HPV complications in mothers and children.

Area of Science:

  • Reproductive Health
  • Pediatric Infectious Diseases
  • Oncology

Background:

  • Human papillomavirus (HPV) is the most common sexually transmitted infection globally.
  • HPV is linked to various cancers, including genital and oropharyngeal types.
  • Pregnancy and infancy present unique risks and transmission routes for HPV.

Purpose of the Study:

  • To review the epidemiology of HPV infection in pregnant women and children.
  • To describe the clinical manifestations of HPV in these populations.
  • To outline current treatment strategies and the role of vaccination.

Main Methods:

  • Comprehensive literature review of HPV epidemiology, clinical presentations, and management.
  • Analysis of transmission routes in infants and children.
  • Evaluation of HPV vaccination efficacy in preventing complications.

Main Results:

  • HPV infection during pregnancy can lead to adverse maternal and infant outcomes.
  • Infants are susceptible to vertical and horizontal HPV transmission.
  • Manifestations range from skin infections to juvenile recurrent respiratory papillomatosis.
  • Vaccination strategies are crucial for primary prevention.

Conclusions:

  • Understanding HPV's impact on pregnancy and childhood is vital.
  • Prompt diagnosis and management are necessary.
  • HPV vaccination is a critical tool for reducing disease burden.

Keywords:
HPVchildrengestationneoplasmsnewborn infantspregnancy complicationsretinoblastoma

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