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Delta-8 Tetrahydrocannabinol Product Impurities
Colleen L Ray1, Madison P Bylo1, Jonny Pescaglia1
1Department of Chemistry, University of Missouri, 601 S. College Avenue, Columbia, MO 65211, USA.
Molecules (Basel, Switzerland)
|October 27, 2022
Summary
Unidentified impurities were found in delta-8 tetrahydrocannabinol (Δ-8 THC) products at levels exceeding stated amounts. This highlights concerns about the safety and accurate labeling of these synthetic cannabinoid items.
Area of Science:
- Cannabinoid chemistry
- Analytical chemistry
- Consumer product safety
Background:
- Delta-8 tetrahydrocannabinol (Δ-8 THC) is a synthetic cannabinoid derived from cannabidiol (CBD).
- There are growing concerns about the presence of unidentified impurities in Δ-8 THC consumer products.
- Inadequate testing by manufacturers and third-party labs may contribute to safety issues.
Purpose of the Study:
- To investigate and quantify unidentified impurities in commercially available Δ-8 THC products.
- To compare detected impurity levels with declared concentrations on certificates of analysis.
- To assess the adequacy of current testing practices for Δ-8 THC products.
Main Methods:
- Analysis of ten Δ-8 THC products, including distillates and vaporizer cartridges.
- Utilized advanced analytical techniques: Nuclear Magnetic Resonance (NMR), High-Performance Liquid Chromatography (HPLC), and Mass Spectrometry (MS).
Main Results:
- Detected several impurities in the tested Δ-8 THC products.
- Impurity concentrations significantly exceeded those reported on certificates of analysis.
- Evidence suggests insufficient product testing by producers and independent laboratories.
Conclusions:
- Commercial Δ-8 THC products contain significant levels of undeclared impurities.
- The synthetic nature of Δ-8 THC and inadequate testing raise concerns about potential health risks.
- Improved analytical methods and regulatory oversight are crucial for ensuring consumer safety.

