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Antibacterial Porous Systems Based on Polylactide Loaded with Amikacin
Marta Glinka1, Katerina Filatova2, Justyna Kucińska-Lipka3
1Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, 11/12 G. Narutowicza Street, 80-233 Gdańsk, Poland.
Molecules (Basel, Switzerland)
|October 27, 2022
Summary
New poly(lactic acid) matrices offer controlled amikacin release for over 60 days. Modified matrices show potential for prolonged drug delivery and antibacterial applications against common pathogens.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Polymer Chemistry
Background:
- Poly(lactic acid) (PLA) matrices are explored for controlled drug release.
- Amikacin is a crucial antibiotic requiring effective delivery systems.
- Chitosan and silica nanocarriers can modify material properties for enhanced drug delivery.
Purpose of the Study:
- To develop and characterize porous poly(lactic acid) matrices for controlled amikacin release.
- To investigate the impact of chitosan and silica nanocarriers on drug loading and release kinetics.
- To evaluate the antibacterial efficacy and physicochemical properties of the developed matrices.
Main Methods:
- Fabrication of porous PLA matrices using surface liquid spraying.
- Incorporation of amikacin, chitosan, and silica nanocarriers.
- In vitro drug release studies following the Kosmyer-Pepas model.
- Antibacterial activity testing against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
- Analysis of transdermal absorption, morphology, elemental composition, and thermogravimetric properties.
Main Results:
- Matrices demonstrated sustained amikacin release over 60 days.
- Drug loading varied based on composition: 25.4 ± 2.2 μg/mg (chitosan), 93 ± 13 μg/mg (SiO2 nanoparticles), and 96 ± 34 μg/mg (unmodified).
- Effective inhibition of tested bacterial strains was observed.
- Release kinetics followed the Kosmyer-Pepas model.
Conclusions:
- Porous PLA matrices, with or without chitosan and silica nanocarriers, provide a viable platform for controlled amikacin delivery.
- The developed materials show promise for treating bacterial infections requiring prolonged antibiotic exposure.
- Further studies on transdermal absorption and material properties support their potential clinical application.
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