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Storage-induced changes in human newborn red cells.

S Horn, D Mazor, E Zmora

    Transfusion
    |September 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

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    Newborn red blood cells show accelerated storage changes compared to adult cells, potentially due to faster adenosine triphosphate (ATP) decline. However, storage in CPDA-1 is better than CPD, and adenosine can partially reverse damage, suggesting transfusion potential.

    Area of Science:

    • Transfusion Medicine
    • Neonatal Hematology
    • Blood Storage

    Background:

    • Fetal red blood cells (RBCs) are adapted for intrauterine environments.
    • Limited understanding exists regarding fetal RBC response to postnatal storage conditions.
    • Neonatal RBCs may exhibit unique metabolic and membrane alterations during storage.

    Purpose of the Study:

    • To investigate metabolic and membrane changes in newborn RBCs during storage.
    • To compare storage responses in citrate-phosphate-dextrose (CPD) and CPDA-1 media.
    • To assess the potential for transfusion of stored neonatal RBCs.

    Main Methods:

    • Storage of newborn RBCs in CPD and CPDA-1 media.
    • Analysis of metabolic changes, including adenosine triphosphate (ATP) levels.

    Related Experiment Videos

  • Evaluation of membrane integrity and storage lesion development.
  • Assessment of storage lesion reversibility with adenosine incubation.

    • Main Results:

    • Newborn RBCs demonstrated accelerated storage-induced changes compared to adult RBCs.
    • Rapid decline in ATP levels was observed in neonatal RBCs during storage.
    • CPDA-1 provided better preservation for fetal RBCs than CPD.
    • Storage lesion was partially reversible with adenosine treatment, similar to adult RBCs.

    Conclusions:

    • Neonatal RBCs are more susceptible to storage-related damage than adult RBCs.
    • Accelerated changes may be linked to faster ATP depletion in fetal cells.
    • Stored neonatal RBCs, particularly in CPDA-1 or improved media, may be suitable for transfusion after several weeks.