Related Experiment Video

Updated: Aug 23, 2025

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model
08:20

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

Published on: December 2, 2022

1.9K

The STING in Non-Alcoholic Fatty Liver Diseases: Potential Therapeutic Targets in Inflammation-Carcinogenesis Pathway

Juan Lv1, Chunlei Xing1, Yuhong Chen1,2

  • 1Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.

Pharmaceuticals (Basel, Switzerland)
|October 27, 2022
PubMed

Insights

Non-alcoholic fatty liver disease (NAFLD) involves immune responses. The stimulator of interferon genes (STING) pathway is implicated in NAFLD development, with current research exploring its inhibitors and agonists.

Area of Science:

  • Immunology
  • Hepatology
  • Molecular Biology

Background:

  • Non-alcoholic fatty liver disease (NAFLD) is a significant global health issue, contributing to mortality and economic burden.
  • Innate immune cells in the liver, such as macrophages and neutrophils, initiate inflammation in response to cellular damage.
  • The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a key regulator of innate immunity.

Purpose of the Study:

  • To summarize the role of STING in the pathogenesis of NAFLD.
  • To review current therapeutic strategies targeting STING for NAFLD.

Main Methods:

  • Literature review of studies on STING and NAFLD.
  • Analysis of the cGAS-STING pathway's involvement in liver inflammation.
  • Compilation of information on existing STING inhibitors and agonists.

Main Results:

  • The cGAS-STING pathway is increasingly recognized for its role in inflammatory, autoimmune, and antiviral responses.
  • Alterations in STING activity are suggested to be involved in the development of various liver disorders, including NAFLD.
  • STING modulators are being investigated as potential therapeutic agents.

Conclusions:

  • STING plays a critical role in the immune response relevant to NAFLD pathogenesis.
  • Targeting the STING pathway presents a potential therapeutic avenue for managing NAFLD.
  • Further research into STING inhibitors and agonists is warranted for NAFLD treatment.
Keywords:
STINGagonistsinflammationinhibitorsnon-alcoholic fatty liver disease

More Related Videos

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.3K
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis08:58

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

16.1K

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
214
Inflammation01:38

Inflammation

Overview
54.4K
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.7K