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Updated: Aug 23, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Pimarane Diterpenes from Fungi.

Ke Ye¹, Hong-Lian Ai¹

¹School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, China.

Pharmaceuticals (Basel, Switzerland)

|October 27, 2022

Summary

Fungi produce diverse pimarane diterpenes, tricyclic compounds with potential medicinal value. This review summarizes 197 fungal-derived pimarane diterpenes, their structures, bioactivities, and biosynthesis.

Area of Science:

Natural Product Chemistry
Mycology
Medicinal Chemistry

Background:

Pimarane diterpenes are tricyclic compounds found in plants and fungi.
Fungi are a vast source of diverse secondary metabolites with significant bioactivity.
These fungal metabolites hold promise for clinical drug development.

Purpose of the Study:

To comprehensively review pimarane diterpenes isolated from fungi.
To summarize the structures and bioactivities of 197 known pimarane diterpenes.
To introduce the biosynthesis and pharmacological research of these compounds.

Main Methods:

Literature review of scientific databases.
Compilation and analysis of structural data.
Summary of reported bioactivities and biosynthetic pathways.

Keywords:

bioactivies biosynthesis fungi pimarane diterpens structures

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Main Results:

Identification and characterization of 197 pimarane diterpenes from fungal sources.
Detailed overview of their diverse chemical structures.
Summary of their known biological activities and potential therapeutic applications.

Conclusions:

Fungal pimarane diterpenes represent a rich resource for novel drug discovery.
Understanding their biosynthesis is key to unlocking their full medicinal potential.
This review provides a valuable reference for researchers in natural product chemistry and pharmacology.