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Updated: Aug 23, 2025
A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
Published on: July 10, 2018
Targeting NMDA Receptor Complex in Management of Epilepsy.
Shravan Sivakumar1, Mehdi Ghasemi1, Steven C Schachter2,3,4
1Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
N-methyl-D-aspartate receptors (NMDARs) are implicated in epilepsy. NMDAR antagonists show promise as anticonvulsive agents for seizure disorders and epilepsy treatment.
Area of Science:
- Neuroscience
- Pharmacology
- Epileptology
Background:
- N-methyl-D-aspartate receptors (NMDARs) are crucial for central nervous system (CNS) neuronal excitability.
- Dysregulation of NMDARs is linked to the pathophysiology of seizure disorders and epilepsy.
Purpose of the Study:
- To review the pathological role of NMDARs in epilepsy.
- To provide an overview of NMDAR antagonists evaluated for anticonvulsive effects.
Main Methods:
- Literature review of clinical and preclinical studies.
- Analysis of NMDAR expression and function in epilepsy models.
- Evaluation of NMDAR antagonists as anticonvulsive agents.
Main Results:
- NMDARs play a significant role in the development and maintenance of epilepsy.
- NMDAR antagonists have demonstrated anticonvulsive properties in various seizure models.
- Clinical studies and preclinical models support the potential of NMDAR modulators in epilepsy treatment.
Conclusions:
- NMDARs are a key target for anticonvulsant therapies.
- Further research into NMDAR antagonists may lead to novel epilepsy treatments.
- Modulating NMDAR function offers a promising therapeutic strategy for seizure disorders.
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