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Updated: Aug 23, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
Published on: June 7, 2024
Cancer Treatment and Immunotherapy during Pregnancy
Antonios Koutras1, Thomas Ntounis1, Zacharias Fasoulakis1
11st Department of Obstetrics and Gynecology, General Hospital of Athens 'ALEXANDRA', National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece.
Cancer treatment during pregnancy is increasingly common. Immunotherapy and other oncological drugs require careful timing, with a focus on maternal and fetal safety, often recommending postponement until after the first trimester.
Area of Science:
- Oncology
- Maternal-Fetal Medicine
- Immunotherapy
Background:
- Increasing incidence of cancer during pregnancy.
- Growing use of immunotherapy for cancer treatment.
- Ethical and therapeutic challenges in treating pregnant cancer patients.
Purpose of the Study:
- To review oncology drug use in gestational cancers.
- To assess appropriateness and timing of treatments.
- To evaluate potential effects on mother and fetus.
Main Methods:
- Literature review of studies on gestational cancer treatment.
- Analysis of oncological drug administration during pregnancy.
- Examination of treatment timing and safety considerations.
Main Results:
- Oncological treatments (drugs, radiation, surgery) are case-dependent.
- Specific focus on the use and effects of immunotherapy during pregnancy.
- Studies indicate delaying oncological drug administration until post-first trimester is often advised.
Conclusions:
- Careful consideration of treatment timing is crucial for maternal and fetal well-being.
- Immunotherapy and other cancer drugs present unique challenges in pregnancy.
- Postponing treatment until after the first trimester is a key consideration.
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