Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Posture Tracking of Active Capsule Endoscopes Integrated with Magnetic Actuation Using Hall-Effect Sensors.

Micromachines·2026

Same author

Non-invasive hemodynamic monitoring during hemorrhage and blood transfusion: opportunities and challenges.

Physiological measurement·2026

Same author

Unsupervised Variational-Autoencoder-Based Analysis of Morphological Representations in Magnetic-Nanoparticle-Treated Macrophages.

Bioengineering (Basel, Switzerland)·2026

Same author

Secure Angle-Based Geometric Elimination (SAGE) for Microrobot Path Planning.

Micromachines·2025

Same author

Parametric Rule-Based Intelligent System (PRISM) for Design and Analysis of High-Strength Separable Microneedles.

Micromachines·2025

Same author

Enhanced Anti-Tumor Effects of Natural Killer Cell-Derived Exosomes Through Doxorubicin Delivery to Hepatocellular Carcinoma Cells: Cytotoxicity and Apoptosis Study.

International journal of molecular sciences·2025

Same journal

RETRACTED: Meligy et al. Therapeutic Potential of Mesenchymal Stem Cells Versus Omega n - 3 Polyunsaturated Fatty Acids on Gentamicin-Induced Cardiac Degeneration. <i>Pharmaceutics</i> 2022, <i>14</i>, 1322.

Pharmaceutics·2026

Same journal

Correction: Mohite et al. Bioactive Compound-Fortified Nanomedicine in the Modulation of Reactive Oxygen Species and Enhancement of the Wound Healing Process: A Review. <i>Pharmaceutics</i> 2025, <i>17</i>, 855.

Pharmaceutics·2026

Same journal

Metal Nanoparticle-Reinforced Hydrogels Applied in the Inhibition of Clinical Pathogens: Structural Features, Mechanisms, and Biomedical Prospects.

Pharmaceutics·2026

Same journal

Development and Evaluation of a Physiologically Based Pharmacokinetic Model for Cipepofol Across Diverse Clinical Populations.

Pharmaceutics·2026

Same journal

Artificial Intelligence in Nanopharmaceutical Development: From Predictive Design to Clinical Translation.

Pharmaceutics·2026

Same journal

Textilinin-1, a Snake Venom-Derived Kunitz-Type Protease Inhibitor, Accelerates Wound Healing Through Anti-Inflammatory, Antibacterial, and Pro-Regenerative Activities.

Pharmaceutics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 23, 2025

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

Acoustically Driven Cell-Based Microrobots for Targeted Tumor Therapy.

Hiep Xuan Cao^1,2, Van Du Nguyen^1,2, Daewon Jung²

¹School of Mechanical Engineering, Chonnam National University, Gwangju 61186, Korea.

|October 27, 2022

Summary

This summary is machine-generated.

This study introduces macrophage-based microrobots (Macbots) for targeted tumor therapy. These Macbots, guided by acoustic fields, demonstrate precise navigation and penetration capabilities for drug delivery.

Keywords:

acoustic manipulation cell-based microrobot targeted drug delivery

More Related Videos

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties

Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties

Published on: May 19, 2023

Related Experiment Videos

Last Updated: Aug 23, 2025

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties

Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties

Published on: May 19, 2023

Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Targeted drug delivery is crucial for effective cancer treatment.
Microrobots offer a promising wireless approach for precise therapeutic agent delivery.
Current methods face challenges in reaching and penetrating solid tumors.

Purpose of the Study:

To develop a novel acoustic manipulation system for controlling microrobots.
To engineer macrophage-based microrobots (Macbots) as drug carriers.
To evaluate the efficacy of Macbots in targeted tumor therapy in vitro.

Main Methods:

Macbots were fabricated incorporating superparamagnetic iron oxide nanoparticles (SPIONs).
An acoustic field was used to manipulate clusters of Macbots along predefined trajectories.
In vitro experiments utilized 3D tumor spheroids to mimic in vivo conditions.

Main Results:

Macbot clusters were precisely manipulated within a 4 × 4 × 4 mm region with <300 μm error.
Microrobots demonstrated controlled rotation in the O-XY plane.
Macbots successfully penetrated a 3D tumor spheroid model.

Conclusions:

Acoustically manipulated Macbots show potential for wireless targeted drug delivery.
The system offers precise control over microrobot positioning and orientation.
Macbots demonstrate feasibility for penetrating solid tumor models in vitro.